Skin Treatment
GMP Certified · Fungicidal · 10mg/kg Once Daily · OEM/ODM Available
Oral systemic antifungal tablets for dogs — fungicidal action against ringworm and dermatophyte infections.
Terbinafine Hydrochloride Tablets is an oral antifungal medication used to treat dermatophyte infections of the skin, hair, and nails in dogs .It is highly effective against ringworm (Microsporum canis, Trichophyton mentagrophytes) and other superficial fungal infections. As a trusted Skin Treatment, it works by inhibiting squalene epoxidase, leading to fungal cell death.
WERVIC, a professional veterinary supplier, offers high‑purity Terbinafine Hydrochloride Tablets with consistent quality, precise dosing, and excellent bioavailability – ideal for veterinary clinics, shelters, and distributors.
Terbinafine hydrochloride tablets are indicated for the systemic treatment of dermatophyte fungal infections in dogs — primarily ringworm (Microsporum canis, Trichophyton mentagrophytes) affecting the skin, hair follicles, and nails.
When oral tablets are the right choice over topical-only treatment:
Widespread lesions covering multiple body areas where topical spray coverage is impractical
Deep follicular infections where topical agents cannot penetrate to the site of infection
Recurring or chronic ringworm that has failed topical monotherapy
Shelter or multi-dog environments with active ringworm outbreaks — combined oral and topical protocol for systematic clearance
Long-coated breeds where topical application to skin surface is difficult
Dogs that failed or showed intolerance to itraconazole or ketoconazole
Terbinafine selectively inhibits fungal squalene epoxidase, an enzyme essential to ergosterol biosynthesis in the fungal cell membrane. The result is a dual mechanism of cell death: squalene accumulates to toxic concentrations within the fungal cell while ergosterol is simultaneously depleted. The fungal cell membrane fails structurally and the organism dies directly.
Azole-class antifungals (itraconazole, ketoconazole, fluconazole) work differently — they inhibit a later step in ergosterol synthesis via lanosterol 14α-demethylase. This produces a fungistatic effect: fungal growth is arrested but the organism is not killed directly. Clearance depends on the animal's immune system finishing the job.
| Parameter | Terbinafine (Allylamine) | Azoles (Itraconazole / Ketoconazole) |
|---|---|---|
| Mechanism of Action | Inhibits Squalene Epoxidase | Inhibits Lanosterol 14α-Demethylase |
| Antifungal Activity | Fungicidal (Kills Fungi) | Fungistatic (Inhibits Fungal Growth) |
| Fungal Clearance | Direct Fungicidal Activity Combined with Host Immune Response | Primarily Dependent on Host Immune Response |
| Risk of Relapse | Lower | Comparatively Higher |
| Hepatotoxicity | Generally Lower Than Ketoconazole | Ketoconazole Has a Higher Risk of Hepatotoxicity |
| Drug Interactions | Fewer Clinically Significant Drug Interactions | More CYP450-Mediated Drug Interactions |
| Parameter | Details |
|---|---|
| Active Ingredient | Terbinafine Hydrochloride |
| Strength | 0.1 g per Tablet (Calculated as C₂₁H₂₅N·HCl) |
| Appearance | Light Yellow Tablet |
| Drug Class | Allylamine Antifungal |
| Target Species | Dogs (For Cats, Terbinafine Spray Is Recommended for Topical Use) |
| Administration Route | Oral Administration |
| Recommended Dosing Frequency | Once Daily |
| Recommended Treatment Duration | 14–28 Consecutive Days* |
| Storage Conditions | Store in a Cool, Dry Place and Protect from Light. Keep Tightly Sealed. |
| Shelf Life | 24 Months |
| Withdrawal Period | Not Applicable** |
| Packaging | Standard Export Packaging or Customized OEM/Private Label Packaging Available |
Standard dose: 10 mg terbinafine hydrochloride per 1 kg body weight, orally, once daily.
Treatment duration: 14 to 28 consecutive days. Do not discontinue early even if lesions appear to resolve — dermatophyte clearance requires completing the full course to prevent relapse.
Practical dosing table:
| Dog Weight | Recommended Daily Dose | Tablet Administration Guide |
|---|---|---|
| 2.5–5 kg | 25–50 mg | ½ Tablet* |
| 5–10 kg | 50–100 mg | ½–1 Tablet |
| 10–20 kg | 100–200 mg | 1–2 Tablets |
| 20–30 kg | 200–300 mg | 2–3 Tablets |
| Over 30 kg | 300 mg or Above | Dosage Determined by a Licensed Veterinarian |
Administration guidance: Give with food to minimize the risk of mild GI upset. Administer at the same time each day to maintain consistent plasma drug levels.
Terbinafine Hydrochloride Tablets (this product) — oral systemic action. Targets the infection from inside out. Preferred for widespread, deep, or recurring infections, and for cases where topical coverage is impractical.
Terbinafine Hydrochloride Spray — topical fungicidal spray. Direct surface-level lesion treatment. Applied twice daily to the affected skin area.
Combined protocol: for moderate to severe ringworm, veterinarians routinely co-prescribe both. The spray addresses surface lesions rapidly while the tablet clears the systemic infection.
Who we supply:
Veterinary pharmaceutical distributors adding oral antifungal SKUs to their dermatology range
Pet health importers sourcing terbinafine as a generic alternative to brand-leader oral antifungals
Veterinary clinic chains and shelter supply procurement teams
Private label brands building companion animal dermatology lines
International distributors serving markets with high ringworm prevalence (Southeast Asia, Latin America, Middle East, parts of Eastern Europe)
OEM/ODM scope:
Custom brand name, logo, and label design in any language (including Portuguese for Brazil/LATAM markets)
Custom tablet strength and coating
Custom packaging: blister count, box dimensions, insert/leaflet language
Regulatory dossier support: GMP certificate, Certificate of Analysis, stability data, efficacy documentation for EU, UK, AU, Southeast Asia, LATAM, Middle East
Lead time: 30–45 days standard.
MOQ: Flexible — contact us with your target market and volume for a project-specific quotation.
Contraindications:
Do not use in breeding dogs, pregnant dogs, lactating bitches, or puppies under 6 months of age (safety studies not conducted)
Do not use in animals with confirmed hepatic or renal insufficiency
Use with caution in dogs under 2.5 kg — administer only under veterinary guidance
Monitoring:
Liver function testing is recommended 2 weeks after initiating treatment, particularly for dogs on courses longer than 14 days. This is standard practice for oral antifungal therapy and should be communicated clearly in product labeling and downstream educational materials.
Adverse reactions:
Mild and transient gastrointestinal effects (reduced appetite, occasional vomiting) are the most commonly reported reactions. These typically resolve without discontinuing treatment. Serious adverse events are rare at therapeutic doses.
What does terbinafine treat in dogs?
Dermatophyte fungal infections — primarily ringworm caused by Microsporum canis and Trichophyton mentagrophytes. Indicated for skin, hair follicle, and nail infections. Most commonly used for widespread, recurring, or treatment-resistant ringworm cases.
What is the terbinafine dosage for dogs?
10 mg per kg body weight, orally, once daily for 14–28 consecutive days. Administer with food. Do not use in dogs under 2.5 kg without veterinary guidance.
Is terbinafine better than itraconazole for dogs?
Both are effective oral antifungals for ringworm. Terbinafine's key advantages are fungicidal action (kills fungi directly rather than inhibiting growth), a lower hepatotoxicity profile than ketoconazole, and fewer drug interactions than azole-class antifungals. Choice depends on clinical history and the prescribing veterinarian's preference.
Can terbinafine tablets be used together with the spray?
Yes — combined oral and topical terbinafine protocol is the standard approach for moderate to severe ringworm. The tablet provides systemic clearance while the spray addresses surface lesions. Both products are manufactured at our GMP-certified facility.
Is liver monitoring required?
Yes. Liver function testing is recommended 2 weeks after starting treatment. This is standard practice for oral antifungal therapy in dogs. Do not use in dogs with existing hepatic insufficiency.
Is OEM/private label available?
Yes — full OEM service including custom branding, tablet strength, packaging, and regulatory dossier support. Available in any language including Portuguese for LATAM markets.
What is the MOQ for wholesale orders?
MOQ is flexible by configuration. Contact us with your estimated volume and target market for project-specific pricing.
