Dewormer
Active Ingredient
Fluralaner
Indications
Used for the treatment of flea and tick infestations on the body surface of cats, and can also be used as an adjuvant treatment for flea-induced allergic dermatitis.
Active Ingredient
Fluralaner
Character
Light brown to dark brown round piece
Indications
Used for the treatment of flea and tick infestations on the body surface of cats, and can also be used as an adjuvant treatment for flea-induced allergic dermatitis.
Specifications
(1) 112.5mg; (2) 250mg; (3) 500mg
Pack size
1 tablet/box or 4 tablets/box
Storage
Store in a sealed container at a temperature below 30℃.
Shelf life
24 months
Calculated based on this product. For oral administration to cats: Administer according to the weight range specified in the table below, once every 12 weeks.
|
Body Weight (kg) |
Specification |
Quantity |
|
≥1.2~≤2.8 |
112.5mg/tablet |
1 tablet |
|
>2.8~≤6.25 |
250mg/tablet |
1 tablet |
|
>6.25~≤12.5 |
500mg/tablet |
1 tablet |
|
>12.5 |
Select a combination of appropriate specifications |
Select a combination of appropriate specifications |
Pharmacodynamics
Fluralaner is an isoxazoline-based insecticide and acaricide. It exerts its effect by antagonizing γ-aminobutyric acid (GABA) receptors and glutamate receptor-gated chloride channels. This antagonism prevents chloride ions from penetrating the postsynaptic membrane, interfering with the transmembrane signal transmission in the nervous system, which leads to neurological disorders in insects and their subsequent death. Fluralaner does not show cross-resistance with dieldrin.
As a systemic antiparasitic drug, Fluralaner provides persistent efficacy in repelling and killing fleas and ticks on the body surface of dogs for up to 12 weeks. It is effective in repelling and killing Ctenocephalides felis (cat flea) and Ctenocephalides canis (dog flea). It acts rapidly on adult fleas and maintains its effect for a long time. Additionally, it can prevent fleas from laying eggs, thereby disrupting the life cycle of fleas. Fluralaner also has a killing effect on Ixodes ricinus (castor bean tick, including larvae, nymphs, and adults), Ixodes hexagonus (six-spotted tick), Ixodes scapularis (deer tick), Ixodes holocyclus (Australian paralysis tick), Dermacentor reticulatus (ornate cow tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick).
Pharmacokinetics
Fluralaner is easily absorbed after oral administration, reaching the maximum plasma concentration within 1 day. Food can promote its absorption. Fluralaner is distributed systemically throughout the body, with the highest concentration in fat, followed by the liver, kidneys, and muscles. It is barely metabolized in dogs, with a plasma elimination half-life of approximately 12 days, which enables Fluralaner to maintain an effective plasma concentration during the administration period. There are individual differences in the maximum plasma concentration and plasma elimination half-life. Approximately 90% of Fluralaner is excreted in its original form via feces, with a small amount excreted through the kidneys.
In individual cats, the following symptoms may be observed shortly after administration: lethargy/tremors/anorexia (accounting for 0.9% of treated cats) or vomiting/excessive salivation (accounting for 0.4% of treated cats); convulsions occur very rarely in cats (less than 0.01% of treated cats).
Cats allergic to this product must not use it. Cats with a history of neurological diseases should use this product with caution.
The interval between administrations must not be less than 8 weeks.
The safety of this product in pregnant and lactating cats has not been studied. It is recommended to determine whether to administer the drug after evaluation by a veterinarian.
Not applicable.
